Drug Discovery

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Drug Discovery
ADME studies

ADME/PK Studies

Gain critical insights into the pharmacokinetics and ADME properties of your compounds. Our studies provide valuable data to guide compound optimization and inform early-stage development decisions. Similarly, PK studies provide a comprehensive view of your compound’s behaviour in vivo.

Absorption Studies
Distribution Studies
Metabolism Studies
Excretion Studies

Permeability/ Transporters

PMPA-GIT
Caco-2/MDCK permeability
Transdermal diffusion

Distribution

Plasma protein binding
Blood to plasma partition

Metabolism

Met ID
Reactive Metabolites
Irreversible CYP inihibition

ADME for Pro Drugs

Assessment of Physicochemical properties:

Solubility at different pH, solubility at different pH

Assessment of enzymatic conversion of prodrug into parent in vitro

In cross species hepatocytes with/without ABT and PMSF
In cross species liver S9/microsomes with/without NADPH
In cross species intestinal microsomes and S9 with/without NADPH
In cross species blood

Optimisation of Prodrugs, IVIVC

PK (rodent), PK (non-rodent), Met id of prodrugs in cross species hepatocytes and cross species intestinal S9 if needed, Caco-2 studies for permeability.

Dose Range finding, Safety/Tox assessment, Interspecies Scaling